A Glimpse from the Past into the Future of Biochemical Measurement and Control

When Monsanto was making the transition to a life science company, I had the opportunity to work on fermenter measurement and control for various genetically engineered products. Important opportunities identified then such as the application of mass spectrometers, dissolved carbon dioxide probes, and inferential measurements of metabolic processes have come to fruition today opening the door to more advanced process analysis and control techniques. Additionally the applications gave me a chance to apply my expertise in pH measurement and control in new ways and dig into the practical aspects of dissolved oxygen measurement and control.

These opportunities and practical considerations were documented in a book Biochemical Measurement and Control, which is now available free electronically via the link http://www.modelingandcontrol.com/biochemicalmeasurement/

This E-book also offers an introduction to importance of biotechnology and a perspective of the future from the past. My expression of gratitude in the Acknowledgement to KSHE Sweetmeats for the inspiration has initiated speculations over the years that are more interesting than the explanation that Sweetmeats is the mascot for a Saint Louis classic rock radio station that I listened to while writing the book.

My latest book Bioprocess Modeling and Control – Maximizing Process Analytical Technology Benefits published by ISA in 2006 provides an updated view and details on new tools for batch modeling, analysis, and control. This ISA book includes the development of neural network inferential measurements of dryer moisture by Washington University in Saint Louis and my first principle dynamic fermentor models for the National Corn to Ethanol Research Center. The book concludes with an excellent review of new technology for batch analytics by the University of Texas.

It is interesting how the past plays into the future. I how have the privilege to participate in a beta test of new PAT tools with Broadley-James for fermenter modeling, analysis, and control of BioNet systems. The beta tests offers a synergistic environment for combining the expertise of Dr Thomas Edgar and Yang Zhang at the University of Texas and many key people at Broadley-James and in DeltaV’s Future Architecture team including my coauthor Michael Boudreau. Another really neat thing about this beta test is that we can extensively share the details of the results.